Endocrine Abstracts

Introduction: Acromegaly is a rare disease characterized by GH and IGF1 hypersecretion and increased cardiovascular mortality. Ultrasonographic measurement of carotid intima media thickness (CIMT) gives substantial information about early atherosclerosis. We aimed to evaluate CIMT and its determinants in a group of acromegaly patient.Patients and methods: Forty-four acromegaly patient and 43 age, sex and body mass index (BMI) matched healthy controls wer...

Background: Primary empty sella is an anatomical term defining the herniation of subarachnoid space within the sella turcica without an underlying factor such as pituitary tumor, surgery, irradiation or trauma.Patients and methods: We retrospectively evaluated clinical, hormonal and radiological data of the patients with primary empty sella syndrome followed in our institution between 2001 and 2012.Results: Ninety-four patients (80...

Introduction: The growth promoting effects of GH and IGF1 has lead to increasing number of cancer surveillence studies in acromegaly so far. We herein aimed to present the prevalance of cancer in acromegaly patients followed in our institution.Patients and design: We retrospectively analyzed medical records of 151 patients with acromegaly (83 females) followed in our department from 2001 to 2012.Results: Overall, cancer was detecte...

TSH supression therapy with thyroid hormone is a mainstay of thyroid cancer treatment. Effectiveness of thyroid hormone therapy may be disrupted by nonadherence of the patient, interfering drugs, foods and intestinal disorders. We here present a case of papillary thyroid cancer with unsuccessful supression therapy.Case: A 38 year old woman, underwent total thyroidectomy for euthyroid multinodular goitre, with a pathological diagnosis of papillary thyroid...

Introduction and aims: Mean platelet volume (MPV) is a newly indicator of platelet activation which was associated with atherosclerosis. There are limited studies in the literature about MPV levels in patients with both hypoparathyroidism and hyperparathyroidism. This preliminary study, we aimed to investigate a relationship with MPV and serum PTH and calcium levels in patients with disorder of calcium metabolism.Materials and methods: Fourty-nine hyperp...

ObjectivesMale prolactinoma patients mostly have hypogonadotropic symptoms. While treatment with dopamine agonists (DAs; such as bromocriptine or cabergoline) leads to recovery of sexual glands, it can lead to impulsive control disorders as an undesirable side effect. The aim of this retrospective study is to determine the level of testosterone that eliminates symptoms, provides fertility and does not cause this undesirable side effect regardless of prol...

Dysregulation of sodium-iodide symporter (NIS) function is common in differentiated thyroid cancer, resulting in sub-optimal radioiodide therapy and poorer clinical outcome. Recent developments in identifying proteins that regulate the function of the sodium iodide symporter have highlighted two proteins involved in internalisation of NIS from the plasma membrane: AP-2 and moesin. Clathrin-mediated endocytosis (CME) of NIS is facilitated through the adaptor protein 2 (AP2) com...

The proto-oncogene pituitary tumor-transforming gene-binding factor (PBF) is upregulated in multiple tumours including thyroid cancer. PBF overexpression mediates tumorigenic processes such as cell motility and accelerates thyroid cancer cell invasion. We have recently shown that both PBF phosphorylation at tyrosine 174 (Y174) and PBF endocytosis are required for PBF-stimulated thyroid and breast cancer cell migration and invasion. This prompted further investigation into a ph...

Objective: Graves’ disease (GD) occurs as a result of genetic and environmental factors that trigger autoimmunity. Some pro-inflammatory cytokines have already been linked to an increased susceptibility of developing GD. Recently, it has been reported that Covid-19 infection and SARS-CoV-2 vaccination trigger the emergence of new GD cases or disease recurrence as environmental factors due to the pandemic. However, there is no data in the literature reporting the effects o...

Background: Paragangliomas (PGLs) and pheochromocytomas (PCCs) arise from chromaffin cells. We evaluated the inflammatory markers. The pan-immune-inflammation value (PIV) has recently been used as a new marker. Therefore, we evaluated the PIV association in patients with PGLs/PCCs.Methods: In the study, the data of 82 patients with PGLs/PCCs who applied between 2005 and 2020 were collected retrospectively from the records. NLR (neutrophil/lymphocyte rati...